The Neurodegeneration Pathobiology Laboratory, (AKA @WalkerNeuroLab), studies the molecular mechanisms of age-related neurodegenerative diseases, with a focus on amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND) and frontotemporal dementia (FTD). We moved to the Queensland Brain Institute at the University of Queensland in April 2018, with the support of the Ross Maclean Fellowship for MND Research. 

 

Projects

Our on-going research projects involve the use of cell and mouse models of disease, with additional studies of human brain and spinal cord samples, to identify the underlying biochemical changes that lead to disease and to test potential therapeutics in pre-clinical studies. We investigate how sub-cellular organelle disruptions, cellular stress mechanisms, protein aggregation and neuronal and glial alterations contribute to disease pathogenesis.