See research from the lab on Google Scholar.

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Recent highlights

Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD
Hedl TJ, San Gil R, Cheng F, Rayner SL, Davidson JM, De Luca A, Villalva MD, Ecroyd H, Walker AK, Lee A
Frontiers in Neuroscience, 13: 548 (2019)

The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD
Berning BA and Walker AK
Frontiers in Neuroscience, 13: 335 (2019)

Casein kinase II phosphorylation of cyclin F as serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex
Lee A, Rayner SL, De Luca A, Gwee SSL, Morsch M, Sundaramoorthy V, Shahheydari H, Ragagnin A, Shi B, Williams KL, Don EK, Walker AK, Zhang KY, Yerbury JJ, Cole NJ, Atkin JD, Blair IP, Molloy MP, Chung RS
Open Biology, 7: 170058 (2017)

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy
Lee A, Rayner SL, Gwee SSL, De Luca A, Shahheydari H, Sundaramoorthy V, Ragagnin A, Morsch M, Radford R, Galper J, Freckleton S, Shi B, Walker AK, Don EK, Cole NJ, Yang S, Williams KL, Yerbury JJ, Blair IP, Atkin JD, Molloy MP, Chung RS
Cellular and Molecular Life Sciences, 75: 335 (2017)

An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice
Walker AK*, Tripathy K*, Restrepo C, Ge G, Xu Y, Kwong LK, Trojanowski JQ, Lee VM-Y
Human Molecular Genetics, 24: 7241 (2015) (*equal contribution)

Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43
Walker AK, Spiller KJ, Ge G, Zheng A, Xu Y, Zhou M, Tripathy K, Kwong LK, Trojanowski JQ, Lee VM-Y
Acta Neuropathologica, 130: 643 (2015)

Astrocytic TDP-43 pathology in Alexander disease
Walker AK*, LaPash Daniels CM*, Goldman JE, Trojanowski JQ, Lee VM-Y, Messing A
The Journal of Neuroscience, 34: 6448 (2014) (*equal contribution)


Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis
Atkin JD, Farg MA, Soo KY, Walker AK*, Halloran M, Turner BJ, Nagley P, Horne MK
Journal of Neurochemistry, 129: 190 (2014) (*cover image)