Recent research publications

2017

Casein kinase II phosphorylation of cyclin F as serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex
Lee A, Rayner SL, De Luca A, Gwee SSL, Morsch M, Sundaramoorthy V, Shahheydari H, Ragagnin A, Shi B, Williams KL, Don EK, Walker AK, Zhang KY, Yerbury JJ, Cole NJ, Atkin JD, Blair IP, Molloy MP, Chung RS
Open Biology

 

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy
Lee A, Rayner SL, Gwee SSL, De Luca A, Shahheydari H, Sundaramoorthy V, Ragagnin A, Morsch M, Radford R, Galper J, Freckleton S, Shi B, Walker AK, Don EK, Cole NJ, Yang S, Williams KL, Yerbury JJ, Blair IP, Atkin JD, Molloy MP, Chung RS
Cellular and Molecular Life Sciences

 

2015

An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice
Walker AK*, Tripathy K*, Restrepo C, Ge G, Xu Y, Kwong LK, Trojanowski JQ, Lee VM-Y
Human Molecular Genetics (*equal contribution)

 

Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43
Walker AK, Spiller KJ, Ge G, Zheng A, Xu Y, Zhou M, Tripathy K, Kwong LK, Trojanowski JQ, Lee VM-Y
Acta Neuropathologica

 

Defects in optineurin and myosin VI mediated cellular trafficking in amyotrophic lateral sclerosis
Sundaramoorthy V, Walker AK, Tan V, Fifita JA, McCann EP, Williams KL, Blair IP, Guillemin GJ, Farg MA, Atkin JD
Human Molecular Genetics

 

2014

Astrocytic TDP-43 pathology in Alexander disease
Walker AK*, LaPash Daniels CM*, Goldman JE, Trojanowski JQ, Lee VM-Y, Messing A
The Journal of Neuroscience (*equal contribution)

 

Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins
Kwong LK, Irwin DJ, Walker AK, Xu Y, Riddle DM, Trojanowski JQ, Lee VM-Y
Acta Neuropathologica Communications

jnc12549-fig-0001-m.png


Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis
Atkin JD, Farg MA, Soo KY, Walker AK*, Halloran M, Turner BJ, Nagley P, Horne MK
Journal of Neurochemistry (*cover image)

 

Recent reviews

2017

Protein quality control and the amyotrophic lateral sclerosis/frontotemporal dementia continuum
Shahheydari H, Ragagnin A, Walker AK, Toth RP, Vidal M, Jagaraj C, Perri E, Konopka A, Sultana J, Atkin JD
Frontiers in Molecular Neuroscience


2014

Involvement of endoplasmic reticulum stress in TDP-43-linked neurodegenerative disease
Walker AK
Journal of Postdoctoral Research